Anatomical Phenotyping of the Knockout Mouse Model of Fragile X Syndrome
نویسندگان
چکیده
Introduction Mutations of the FMR-1 (Fragile X Mental Retardation 1) gene cause a genetic condition know as Fragile X Syndrome (FXS). FXS is the most common inherited cause of mental retardation. The Fragile X knockout mouse (FX KO) is the most widely used animal model of FXS (1). Anatomical phenotyping in the mouse brain using Magnetic Resonance Imaging (MRI) has been shown in a number of mutants to be quite useful in determining specific volumetric changes (2). The purpose of this study was to assess anatomical changes between FX KO and wild type (WT) mice.
منابع مشابه
Anatomical phenotyping in a mouse model of fragile X syndrome with magnetic resonance imaging
Fragile X Syndrome (FXS) is the most common single gene cause of inherited mental impairment, and cognitive deficits can range from simple learning disabilities to mental retardation. Human FXS is caused by a loss of the Fragile X Mental Retardation Protein (FMRP). The fragile X knockout (FX KO) mouse also shows a loss of FMRP, as well as many of the physical and behavioural characteristics of ...
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